منابع مشابه
Monoclonal antibody targeting of liposomes to mouse lung in vivo.
A monoclonal antibody (MoAb), 273-34A, specifically binds to an epitope expressed almost exclusively on capillary endothelial cells of the lung. Within 15 min after i.v. injection, approximately 80 to 85% of the injected radioiodinated MoAb 273-34A accumulates in the lung. Approximately 90 to 95% of the recovered dose is found in the lung for up to 1 week postinjection. Ratios of MoAb 273-34A t...
متن کاملTumor-directed targeting of liposomes.
Tumor-specific targeting is a critical goal in the research area of liposomal drug delivery. Identification of the specific interactions between ligands and target tumor cells is a principle prerequisite in achieving this goal. Generally, tumor cells aberrantly express tumor-associated antigens that can be utilized as appropriate target molecules. Monoclonal antibodies against tumor-associated ...
متن کاملPirfenidone-loaded liposomes for lung targeting: preparation and in vitro/in vivo evaluation
BACKGROUND The purpose of this study was to develop novel pirfenidone (PFD)-loaded liposomes for targeting to the lung. METHODS The liposomes were prepared by the film hydration method, and their in vitro/vivo characteristics were evaluated. RESULTS The PFD liposomes appeared visually as green to yellowish suspensions and were spherical in shape. The particle size was 582.3±21.6 nm and the ...
متن کاملTargeting of small unilamellar liposomes to the galactose receptor in vivo.
Intravenously administered phospholipid liposomes are known to interact with plasma high-density lipoproteins, which remove phospholipid molecules from the bilayers, thus leading to vesicle destabilization. Consequently, drugs that may have been originally entrapped leak out into the circulation to acquire their own clearance rates and tissue distribution. The destabilized liposomes and drugs t...
متن کاملIn vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes.
In adoptive cell therapy (ACT), autologous tumor-specific T-cells isolated from cancer patients are activated and expanded ex vivo, then infused back into the individual to eliminate metastatic tumors. A major limitation of this promising approach is the rapid loss of ACT T-cell effector function in vivo due to the highly immunosuppressive environment in tumors. Protection of T-cells from immun...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2000
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.23.791